2010 Mercedes-Benz E-Class: What's New, Specs & Features

Last updated August 4, 2026

The 2010 Mercedes-Benz E-Class is a full redesign, led by the new W212 sedan and a new E-Class coupe that replaces the CLK. It also gains a more modern cabin and several standard safety features.

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About the 2010 Mercedes-Benz E-Class

4th generation W212 sedan / first-year C207 coupe; first U.S. model year for this redesigned E-Class family, with the W212-based E 63 AMG arriving for 2010 as well.

Mercedes-Benz positions the 2010 E-Class as its benchmark midsize luxury car: a model built around safety, long-distance comfort, solid craftsmanship, and advanced technology rather than one single gimmick. It is sold as an all-around premium car that can be tailored in character through sedan or coupe body styles, Sport or Luxury themes, V6 or V8 power, all-wheel drive, or full AMG performance, while keeping the same core E-Class focus on comfort, confidence, and prestige.

The E 350 is the comfort-focused core model, while the E 550 adds a 382-hp V8 and richer standard equipment. All-wheel-drive sedan versions provide extra bad-weather traction, and the E 63 AMG tops the range with a 518-hp V8, a quicker-shifting sport transmission, upgraded suspension, and stronger brakes.

What changed, by category

Structural

The sedan moves to the new W212 generation. A new pillarless C207 E-Class coupe also joins the family as the replacement for the CLK.

Styling

The sedan and coupe receive new exterior designs and redesigned cabins.

Safety

Standard safety equipment adds ATTENTION ASSIST driver-drowsiness monitoring, a driver knee airbag, and front pelvic airbags.

Tech

A new COMAND control knob and 7-inch central display arrive across the range. Premium audio and satellite radio change from standard to optional on the E 350 and E 550 models, including their all-wheel-drive versions.

Powertrain

The E 320 BLUETEC diesel leaves the lineup. The redesigned E 63 AMG gains a new seven-speed sport transmission and updated performance controls.

2010 Mercedes-Benz E-Class specs and features by trim

Feature	2010 Mercedes-Benz E-ClassE 3503 in stock	2010 Mercedes-Benz E-ClassE 5502 in stock	2010 Mercedes-Benz E-ClassE 63 AMG0 in stock	2010 Mercedes-Benz E-ClassE 350 4MATIC1 in stock	2010 Mercedes-Benz E-ClassE 550 4MATIC1 in stock
Engine	V6, 3.5 Liter	V8, 5.5 Liter	V8, 6.3 Liter	V6, 3.5 Liter	V8, 5.5 Liter
Transmission	Auto, 7-Spd Touch Shift	Auto, 7-Spd Touch Shift	Auto, 7-Spd SPEEDSHIFT	Auto, 7-Spd Touch Shift	Auto, 7-Spd Touch Shift
Drivetrain	RWD	RWD	RWD	4MATIC AWD	4MATIC AWD
Fuel Type	Gas	Gas	Gas	Gas	Gas
MPG City	17–18 mpg	15–16 mpg	13 mpg	17 mpg	15 mpg
MPG Highway	26 mpg	23–24 mpg	20 mpg	24 mpg	23 mpg
Horsepower	268 hp	382 hp	518 hp	268 hp	382 hp
Torque	258 lb-ft	391 lb-ft	465 lb-ft	258 lb-ft	391 lb-ft
Max Towing	1654 lb	1654 lb		1654 lb	1654 lb
Trunk/Cargo	15.9–19.1 cu-ft	15.9–19.1 cu-ft	15.9 cu-ft	19.1 cu-ft	19.1 cu-ft
Rear Legroom	33–35.8 in	33–35.8 in	35.8 in	35.8 in	35.8 in
Seats	4–5	4–5	5	5	5
Doors	2–4	2–4	4	4	4
Safety & Security
Adaptive Cruise Control
Alarm System
Blindspot Sensors
Lane Departure Warning
Night Vision System
Park Assist
Rear View Camera
Exterior Features
Alloy Wheels
Fog Lights
Power Moonroof
Panorama Moon Roof
Power Close Liftgate/Trunk
Rear Spoiler
Entertainment & Electronics
Bluetooth
Front DVD Entertainment System
Navigation System
Premium Audio
Comfort & Convenience
Dual-Zone Climate Control
Folding Rear Seat
Heated Front Seats
Leather Seats
Massage Front Seat
Proximity Keyless Entry
Rear Window Shades
Remote Start
Ventilated Front Seats

How the 2011 Mercedes-Benz E-Class compares

The biggest change for the 2011 Mercedes-Benz E-Class is a broader lineup, led by the new Cabriolet and the return of the Wagon. The BlueTEC diesel also joins the U.S. range nationwide, while upgraded driver-assistance systems and a few trim-level equipment changes round out the year.

See the full 2011 changes

Frequently asked questions

Is the 2010 Mercedes-Benz E-Class fully redesigned?

Yes. The 2010 E-Class sedan begins the new W212 generation with a new body, cabin, safety package, and electronics. The E 63 AMG also moves to the W212-based design.

Did the 2010 E-Class coupe replace the CLK?

Yes. The new pillarless 2010 E-Class coupe takes over the role previously filled by the Mercedes-Benz CLK and shares the E-Class name with the redesigned sedan.

Does the 2010 E-Class still have a diesel model?

No. The E 320 BLUETEC diesel was dropped for 2010, leaving V6 and V8 gasoline models in this year’s lineup.

What safety features were added to the 2010 E-Class?

The 2010 E-Class adds standard driver-drowsiness monitoring, a driver knee airbag, and front pelvic airbags. Mercedes calls its drowsiness-monitoring system ATTENTION ASSIST.

How different is the 2010 E-Class from the 2009 model?

The 2010 model is substantially different from the 2009 E-Class because it starts a new sedan generation and introduces an E-Class coupe in place of the CLK. It also has a redesigned cabin, updated controls, and added standard safety equipment, although premium audio and satellite radio became optional on the E 350 and E 550 models.