| Includes | RX 350h, RX 350h F SPORT Design, RX 350h Luxury, RX 350h Premium, RX 350h Premium+, RX 450h, RX 450h F SPORT, RX 450h F SPORT Handling, RX 450hL, RX 450hL Luxury, RX 500h F SPORT Performance33 in stock | | | RX 350 F SPORT, RX 350 F SPORT Design, RX 350 F SPORT Handling, RX 350 F Sport Crafted Line14 in stock | | |
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| Powertrain character | Hybrid; four-cylinder or V6 by version | 2.4L turbo gas | Gas; recent 2.4L turbo | Gas; V6 or 2.4L turbo by year | 2.5L plug-in hybrid | Gas; V6 RX L or recent 2.4L turbo |
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| Power output | 246 hp 350h; 308 hp 450h; 366 hp 500h | 275 hp | 275 hp in recent models | 275 hp recent; older V6 295 hp | 304 hp | 275 hp recent; RX 350L 290 hp |
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| Recent-model city/highway MPG | 350h: 37 / 34; 500h: 27 / 28 mpg | 22 / 29 mpg | 22 / 29 mpg | 21–22 / 28–29 mpg | 37 / 34 mpg | 22 / 29 mpg |
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| F SPORT role | Design, Handling, and 500h Performance versions | — | — | Design for looks; Handling for sharper responses | — | — |
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| Cabin focus | Ranges from core comfort to Luxury and F SPORT | Front-seat comfort and convenience | Core comfort | Bolstered seats and sport details | Premium or comfort-focused Luxury | Richer materials and rear-seat comfort |
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| Third-row branch | RX 450hL and RX 450hL Luxury | — | — | — | — | RX 350L and RX 350L Luxury |
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| Plug-in electric range | Non-plug-in hybrid | Not a plug-in | Not a plug-in | Not a plug-in | EPA-estimated 38 miles | Not a plug-in |
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