2021 Mercedes-Benz AMG E-Class: What's New, Specs & Features

Last updated August 4, 2026

2021 Mercedes-Benz AMG E-Class

The biggest change for the 2021 Mercedes-Benz AMG E-Class is a broad mid-cycle refresh, not a full redesign. It brings updated styling, touch-operated MBUX infotainment, a new AMG steering wheel, and a more comfortable suspension setup for the E 63 S.

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About the 2021 Mercedes-Benz AMG E-Class

Fifth-generation E-Class family, mid-cycle refresh year; the sedan-based generation began for 2017, with the related coupe and cabriolet following for 2018.

The AMG E-Class combines the passenger space, cabin comfort, and everyday usefulness of Mercedes’ midsize luxury car with much stronger engines, variable AWD, adaptive air suspension, and driver-adjustable performance settings. It serves shoppers who want one vehicle for commuting, long trips, and fast back-road driving. Its unusual breadth is a key distinction: the 2021 range includes sedan, coupe, cabriolet, and high-performance wagon body styles.

The E 53 is the more balanced daily driver, pairing a 429-hp mild-hybrid six-cylinder engine with variable AWD and adaptive air suspension in sedan, coupe, and convertible forms. The E 63 S is the more intense sedan or wagon, with a 603-hp twin-turbo V8, variable AWD, Drift mode, and an electronic limited-slip rear differential. Both use dual 12.3-inch displays with Apple CarPlay and Android Auto.

What changed, by category

Styling
Mercedes revised the grille, bumpers, headlights, and taillights across the AMG E-Class range. The E 63 S received a distinctive vertical-slat grille.
Tech
Dual 12.3-inch displays gained touch-operated MBUX infotainment with natural-language voice control, replacing the previous COMAND system. A new touch-sensitive AMG Performance steering wheel added integrated drive-setting controls. A heated steering wheel became standard on the E 63 S.
Safety
Park Assist and a 360-degree camera became standard on the E 53.
Ride and handling
The E 63 S received recalibrated air suspension designed to provide a softer, more comfortable everyday ride.

2021 Mercedes-Benz AMG E-Class specs and features by trim

Feature
2021 Mercedes-Benz AMG E-ClassE 53 AMG1 in stock
2021 Mercedes-Benz AMG E-ClassE 63 S AMG2 in stock
EngineV6, Twin Turbo, 3.0 LiterV8, Twin Turbo, 4.0 Liter
TransmissionAutomatic, 9-Spd w/AMG SPEEDSHIFT TCTAutomatic, 9-Spd w/AMG SPEEDSHIFT MCT
DrivetrainAWDAWD
Fuel TypeGasGas
MPG City21–22 mpg16 mpg
MPG Highway27–29 mpg23 mpg
Horsepower429 hp603 hp
Torque384 lb-ft627 lb-ft
Trunk/Cargo9.5–13.1 cu-ft13.1–35 cu-ft
Rear Legroom34.1–36.2 in36.1–36.2 in
Seats55
Doors2–44
Adaptive Cruise Control
Adaptive Headlights
Alarm System
Automatic Emergency Braking
Automatic High Beams
Blindspot Sensors
Lane Departure Warning
Park Assist
360 Camera
Alloy Wheels
LED Headlights
Power Moonroof
Panorama Moon Roof
Power Retractable Soft Top
Rear Spoiler
Navigation System
Premium Audio
Smartphone Interface
Aluminum Interior Trim
Dual-Zone Climate Control
Rear Air Conditioning
Heated Front Seats
Heated Rear Seats
Heated Steering Wheel
Leather Seats
Proximity Keyless Entry
Rear Window Shades
Remote Start
Ventilated Front Seats

How the 2022 Mercedes-Benz AMG E-Class compares

The biggest change for the 2022 Mercedes-Benz AMG E-Class is the loss of the E 63 S, leaving the E 53 as the sole trim. Otherwise, this is a lightly changed year rather than a redesign.

Frequently asked questions

Was the 2021 Mercedes-Benz AMG E-Class fully redesigned?

No. The 2021 AMG E-Class received a mid-cycle refresh with updated exterior styling, cabin controls, infotainment, and steering-wheel design, while the underlying generation carried over.

What infotainment change did the 2021 AMG E-Class receive?

The 2021 AMG E-Class gained touch-operated MBUX infotainment with natural-language voice control. It runs through the dual 12.3-inch displays and replaces the earlier COMAND interface.

Did the 2021 AMG E-Class engines change from 2020?

No. The E 53 retained its 429-hp mild-hybrid turbocharged inline-six, while the E 63 S retained its 603-hp twin-turbo V8.

Did the 2021 AMG E 63 S become more comfortable?

Yes. Mercedes recalibrated the E 63 S air suspension for a softer everyday ride while retaining its adaptive damping and high-performance hardware.

What equipment became standard on the 2021 AMG E-Class?

The E 53 made Park Assist and a 360-degree camera standard for 2021. The E 63 S made a heated steering wheel standard.