2021 Mercedes-Benz AMG CLS: What's New, Specs & Features
Last updated August 4, 2026
The biggest change for the 2021 Mercedes-Benz AMG CLS 53 is its new 12.3-inch touchscreen with the MBUX interface, voice control, and a haptic console touchpad. It is otherwise a light update, with the same engine, AWD system, styling, and suspension as before.
About the 2021 Mercedes-Benz AMG CLS
3rd generation (C257), third and final US model year for the AMG CLS 53; the generation began for 2019, and this trim was dropped from the US range for 2022.
Mercedes positions the AMG CLS as a sleek four-door luxury performance car for drivers who value dramatic coupe-like styling without giving up rear doors and five-passenger seating. Its defining combination is a smooth, electrically assisted inline-six, secure AWD, adaptive air suspension, and a technology-rich cabin. Compared with a conventional luxury sedan, the CLS favors a lower roofline and stronger visual presence; compared with a dedicated sports car, it places more emphasis on comfort and long-distance usability.
Mercedes positioned the CLS 53 as the athletic version of its sleek four-door coupe, balancing quick performance with long-distance comfort. Its signature hardware includes a 429-hp electrified inline-six, fully variable AWD, a nine-speed automatic, and adaptive air suspension. The cabin pairs twin 12.3-inch displays with navigation, Apple CarPlay, Android Auto, Burmester audio, and heated memory front seats.
What changed, by category
2021 Mercedes-Benz AMG CLS specs and features by trim
| Feature | |
|---|---|
| Engine | 6-Cyl, Turbo, 3.0 Liter |
| Transmission | Automatic, 9-Spd w/AMG SPEEDSHIFT TCT |
| Drivetrain | AWD |
| Fuel Type | Gas |
| MPG City | 21 mpg |
| MPG Highway | 26 mpg |
| Horsepower | 429 hp |
| Torque | 384 lb-ft |
| Trunk/Cargo | 11.9 cu-ft |
| Rear Legroom | 35 in |
| Doors | 4 |
Frequently asked questions
What is the biggest change to the 2021 Mercedes-Benz AMG CLS 53?
The biggest change is a new 12.3-inch touchscreen running the MBUX infotainment system. It brings natural-language voice control and a haptic touchpad on the center console.
Did the 2021 Mercedes-Benz AMG CLS 53 get any engine or drivetrain changes?
No, the engine and drivetrain carry over. The 2021 CLS 53 keeps its 429-hp 3.0-liter electrified inline-six, nine-speed automatic, and fully variable AWD.
What safety equipment became standard on the 2021 AMG CLS 53?
The surround-view camera system became standard for 2021. The advanced driver-assistance package remained separate and should not be assumed to be fitted to every vehicle.
Is the 2021 AMG CLS 53 a major upgrade over the 2020 model?
No, it is a focused cabin-technology update rather than a major mechanical redesign. The 2021 model is most appealing over the 2020 if the newer touchscreen, MBUX voice controls, standard surround-view cameras, and standard rear sunshade matter to you.
Was 2021 the final US model year for the AMG CLS 53?
Yes, 2021 was the third and final US model year for this generation of the AMG CLS 53. Mercedes dropped the trim from the US range for 2022.